TGF-β: The Double-Edge Sword in Cancer Progression

Imagine a powerful sword that can both protect and destroy. This is like the transforming growth factor β (TGF-β). It’s a complex pathway that’s key in cancer’s growth and spread. TGF-β can act as a shield or a sword, depending on the cancer’s stage and setting. At the core of TGF-β’s mystery are three main types: TGF-β1, TGF-β2, and TGF-β3. Each type has its own…

Wnt Signaling: The Master Regulator of Cancer Stemness

Imagine a bustling city with towering skyscrapers. Each one represents growth and progress. The human body is like this city, with complex pathways controlling its functions. The Wnt signaling pathway is at the heart of this network, key to understanding cancer stemness. In cancer research, the Wnt pathway is crucial. It shapes tumor growth, recurrence, and spread. This pathway controls cell growth, differentiation, and self-renewal.…

Immunoediting: How Cancers Evade Immune Detection

Imagine a battle where the body’s immune system fights against cancer cells. This fight, called cancer immunoediting, decides if a tumor will be stopped, controlled, or grow. You’re about to learn how cancer cells outsmart the immune system. The idea of cancer immunoediting has grown since Ehrlich first suggested it in 1909. It now shows how cancer and the immune system interact. This process has…

Notch Signaling: Cell Fate Decisions in Cancer

Imagine a world where cell fate is like a dance, with each step choreographed for life’s harmony. This is the Notch signaling pathway, crucial for cell destiny, mainly in cancer. The Notch pathway was first found in fruit flies over a century ago. It’s now key in cancer development and growth. It controls cell processes like growth, survival, and differentiation, affecting health and disease balance.…

GSK3 Signaling: Where Metabolism Meets Cancer Growth

Imagine a master key that unlocks the mysteries of cellular energy balance and cancer progression. That key is GSK3, a fascinating enzyme that stands at the crossroads of metabolism and cancer. Its story is one of intricate signaling cascades. The delicate interplay between GSK3, β-catenin, and metabolic pathways holds the key to understanding and potentially treating a wide range of diseases. GSK3, short for Glycogen…

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