The STROBE-MR checklist is the 20-item reporting standard for studies that use genetic variants as instrumental variables to estimate causal effects. Skrivankova and colleagues published it in 2021 as a statement in JAMA and as a long explanation and elaboration paper in the BMJ [1][2]. The authors encourage journals to ask for completed checklists at submission. This guide explains what each item asks, shows where…
Reviewers read your figures before they read your methods. The clinical research graphs that survive peer review share one trait: each one answers a single question, and the reader can see the answer in under ten seconds. This guide covers the 10 plots a clinical researcher meets most often, from the CONSORT flow diagram to the heatmap. For each one you get a real published…
Complete-case analysis is the quiet default in trauma registry research. Drop the rows with a missing GCS, blood pressure, or respiratory rate, fit the model on whatever is left, and report the result. A 2018 systematic review of 539 trauma registry manuscripts found that more than half either never mentioned data completeness or mentioned missing data without saying how it was handled, which means complete-case…
The National Trauma Data Bank and its successor, the American College of Surgeons Trauma Quality Programs participant use file, now draw on more than 900 participating trauma centres across the United States. Scale gets treated as a substitute for rigour more often than it should. A 2018 systematic review of 539 trauma registry manuscripts published between January 2015 and March 2017 found that 38.6% never…
A Mendelian randomization power calculation is the one step in the whole pipeline that costs nothing to run and gets skipped anyway. Rosas-Chavez and Merriman audited 86 two-sample MR studies of hyperuricaemia and gout published between 2016 and 2024 and found that 59 percent addressed power at all, which means 41 percent reported a causal estimate, positive or null, with no statement of whether the…
