Description
Secondary & Post-Hoc Analysis Manuscripts
GPP 2022-aligned secondary publication development for subgroup analyses, exploratory endpoints and post-hoc investigations. We help you communicate additional clinical trial insights transparently, with appropriate statistical caveats and ICMJE authorship standards maintained.
Service Details
| Timeline | Standard: 8-12 weeks | Complexity dependent |
| Best for | Secondary publications from clinical trials, including subgroup, exploratory and post-hoc analyses |
| Standards | GPP 2022, ICMJE, CONSORT Extension (harms, PROs, abstracts), STROBE |
| Transparency | Post-hoc/exploratory designation, multiplicity acknowledgment, hypothesis-generating language and a cross-reference to the primary publication |
Compliance Framework
- GPP 2022 – Secondary publication guidance
- ICMJE – Authorship and transparent reporting
- CONSORT Extension – Harms, PROs, abstracts
- STROBE – Observational component reporting
Analysis Types
- Pre-specified subgroup analyses
- Post-hoc exploratory analyses
- Pooled/integrated efficacy analyses
- Pooled safety analyses
- Long-term extension data
- Patient-reported outcome (PRO) analyses
- Biomarker correlation studies
- Health economic analyses
Transparency Requirements
- Clear designation as post-hoc/exploratory
- Multiplicity acknowledgment
- Hypothesis-generating language
- Primary publication cross-reference
How It Works
- Send us your analysis results and details of the primary publication, plus your target journal if you have one
- We draft the manuscript, clearly designating any post-hoc or exploratory analyses and acknowledging multiplicity
- The authors review the draft, and we revise based on their feedback
- You receive the final manuscript, written in hypothesis-generating language and cross-referenced to the primary publication
Which Service Do You Need?
This service is for publications that build on a trial’s primary results. If the primary publication itself still needs to be written, see Primary Manuscript Development. To plan primary and secondary publications across a clinical program, see Strategic Publication Planning.
Frequently Asked Questions
How are post-hoc results presented?
They are clearly designated as post-hoc/exploratory, multiplicity is acknowledged, the language is hypothesis-generating, and the paper cross-references the primary publication.
Which reporting guidelines apply?
GPP 2022 secondary publication guidance, ICMJE authorship and transparent reporting, CONSORT extensions for harms, PROs and abstracts, and STROBE for any observational components.
How long does it take?
The standard timeline is 8-12 weeks, depending on the complexity of the analyses.
Get started: add this service to your cart, or email co*****@*******se.com with a summary of your analyses and target journal.
