Guidelines
PRISMA 2020 Guidelines: Complete Checklist for Systematic Reviews
Master the updated PRISMA 2020 checklist with our comprehensive guide. Includes downloadable templates and real-world examples for your systematic review.
PRISMA 2020 & GRADE Compliant
Professional Systematic Review & Meta-Analysis Service
Publication-ready evidence synthesis with expert statistical analysis. Forest plots, funnel plots, heterogeneity testing, and GRADE assessments from PhD biostatisticians.
500+
Reviews Completed
8-16
Week Delivery
12+
Languages
Evidence Synthesis & Statistical Analysis
Comprehensive research support
Systematic Reviews
PRISMA flow, RoB/NOS/JBI quality assessment
Meta-Analysis
Forest plots, funnel plots, I² heterogeneity
Network Meta-Analysis
SUCRA rankings, league tables, consistency
Review Articles
Narrative & scoping reviews
Starting from USD $250
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Statistical Analysis Expertise:
Forest Plots
Funnel Plots
I² Heterogeneity
Sensitivity Analysis
Subgroup Analysis
Publication Bias
GRADE Assessment
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Evidence Synthesis & Statistical Analysis Services
All services follow the highest ethical standards in academic publishing. We work collaboratively with researchers, ensuring complete transparency and adherence to international guidelines.
Most Popular
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Systematic Review Writing
Comprehensive, PRISMA 2020-compliant systematic reviews developed in close collaboration with you. We guide you through methodology decisions, ensure you understand every step, and maintain complete transparency throughout the process.
Ethical Compliance
What's Included
- PROSPERO registration support & protocol development
- Multi-database search (PubMed, Cochrane, Scopus, EMBASE)
- Quality assessment (RoB 2.0, NOS, JBI, AMSTAR-2)
- PRISMA 2020 flow diagram & checklist
- Detailed methodology discussions with you
Starting from
$250
Based on study count
Statistical Analysis
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Meta-Analysis Services
Expert statistical pooling with comprehensive heterogeneity assessment, publication bias testing, and sensitivity analyses. We explain all statistical methods and ensure you can confidently present and defend your results.
Ethical Compliance
Statistical Outputs
- Forest plots with pooled effect sizes (OR, RR, MD, SMD)
- Funnel plots & Egger's test for publication bias
- I² heterogeneity & Cochran's Q test
- GRADE evidence certainty assessment
- Full statistical code & methodology training
Starting from
$500
Add-on or standalone
Advanced Analysis
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Network Meta-Analysis (NMA)
Compare multiple interventions simultaneously with advanced Bayesian or frequentist methods. We ensure you understand the complex methodology and can present findings to any audience with confidence.
Ethical Compliance
Advanced Outputs
- Network geometry plots & evidence maps
- SUCRA rankings & rankograms
- League tables with all pairwise comparisons
- Node-splitting for inconsistency assessment
- CINeMA confidence assessment
Starting from
$1,500
Based on network complexity
Quick Turnaround
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Review Articles
Narrative and scoping reviews developed collaboratively with you. We synthesize the literature while you provide subject expertise and intellectual direction. Your ideas, our writing support.
Ethical Compliance
Review Types
- Narrative reviews with thematic synthesis
- Scoping reviews (JBI/PRISMA-ScR methodology)
- Rapid reviews for time-sensitive needs
- State-of-the-art & expert opinion articles
- Clear acknowledgment of writing assistance
Starting from
$1,000
Fastest delivery option
PRISMA-Compliant Workflow
Our Collaborative 6-Step Process
We work alongside you at every stage, ensuring you understand and approve each methodological decision. Your intellectual contribution drives the research.
Step 1
Consultation & Protocol Development
We begin with a detailed discussion of your research question, objectives, and methodology preferences. Together, we develop a PROSPERO-ready protocol that you review and approve.
PICO Framework
Protocol Draft
PROSPERO Registration
Your input: Research question & objectives
Week 1-2
Step 2
Comprehensive Literature Search
Our information specialists conduct systematic searches across multiple databases (PubMed, Cochrane, Scopus, EMBASE, Web of Science). You review and approve the search strategy.
Search Strategy
Database Results
Deduplication
Your input: Approve search terms & databases
Week 2-3
Step 3
Screening & Study Selection
Dual independent screening of titles, abstracts, and full texts against your pre-defined inclusion criteria. Conflicts resolved by discussion. You have final say on borderline cases.
PRISMA Flow Diagram
Exclusion Reasons
Included Studies List
Your input: Final decisions on borderline studies
Week 3-5
Step 4
Data Extraction & Quality Assessment
Systematic data extraction using standardized forms. Risk of bias assessment using validated tools (RoB 2.0, NOS, JBI). You review extracted data for accuracy and completeness.
Data Extraction Tables
RoB Assessment
Evidence Tables
Your input: Verify data accuracy & clinical context
Week 5-8
Step 5
Statistical Analysis & Synthesis
Meta-analysis with forest plots, funnel plots, heterogeneity testing (I², Q-test), and sensitivity analyses. We explain all methods and provide complete statistical code for reproducibility.
Forest Plots
Funnel Plots
GRADE Tables
R/Stata Code
Your input: Interpret clinical significance of results
Week 8-10
Step 6
Manuscript Writing & Submission Support
Publication-ready manuscript following target journal guidelines. Cover letter, PRISMA checklist, and supplementary materials. Revision support for peer review feedback included.
Full Manuscript
Cover Letter
PRISMA Checklist
Revision Support
Your input: Final review, authorship & submission
Week 10-12
Find Your Service
Choose by Your Research Field
Select your research area to see recommended services tailored to your methodology needs and publication goals.
Medical & Clinical Research
RCTs, clinical interventions, drug efficacy, surgical outcomes, diagnostic accuracy studies
Clinical Trials
RCT Meta-Analysis
Cochrane Style
PRISMA
Complete SR + Meta-Analysis
Medium Package
$2,800 / 10-12 weeks
- 16-40 included studies
- Forest plots & funnel plots
- I² heterogeneity analysis
- GRADE evidence tables
Choose this if:
"You're reviewing clinical trials or intervention studies with quantitative outcomes to pool statistically."
Complete SR + Meta-Analysis
Small Package
$1,800 / 8-10 weeks
- Up to 15 included studies
- Full statistical analysis
- PRISMA 2020 compliant
- Subgroup analysis
Choose this if:
"You have a focused clinical question with a limited but high-quality evidence base."
Network Meta-Analysis
Basic Package
$1,500 / 4-6 weeks
- Compare 3-5 treatments
- SUCRA rankings
- League tables
- Network geometry plot
Choose this if:
"You need to compare multiple drug treatments or interventions when direct head-to-head trials are limited."
Network Meta-Analysis
Standard Package
$2,500 / 6-8 weeks
- Compare 6-10 treatments
- Inconsistency assessment
- Bayesian or frequentist
- CINeMA confidence
Choose this if:
"You're developing clinical guidelines or comparing multiple treatment options for a condition."
Systematic Review
Enterprise Package
$4,200 / 14-16 weeks
- 81+ included studies
- Cochrane-level rigor
- Multiple reviewers
- Comprehensive search
Choose this if:
"You need a definitive, Cochrane-style review on a broad clinical topic with extensive literature."
Standalone
Meta-Analysis
$1,000 / 2-4 weeks
- You provide extracted data
- Complete statistical analysis
- All plots & figures
- R/Stata code provided
Choose this if:
"You've already completed the SR and have extracted data ready for statistical pooling."
Systematic Review Only
Medium Package
$2,200 / 10-12 weeks
- 16-40 included studies
- Narrative synthesis
- No statistical pooling
- Quality assessment
Choose this if:
"Your studies are too heterogeneous to pool statistically, or you need qualitative synthesis only."
Scoping Review
PRISMA-ScR Compliant
$1,200 / 6-8 weeks
- Evidence mapping
- JBI methodology
- Gap identification
- PRISMA-ScR checklist
Choose this if:
"You want to map the evidence landscape in an emerging clinical area or identify research gaps."
Public Health & Epidemiology
Observational studies, prevalence research, risk factors, cohort studies, population health
Prevalence
Cohort Studies
Risk Factors
MOOSE
Complete SR + Meta-Analysis
Large Package
$3,800 / 12-14 weeks
- 41-80 included studies
- High heterogeneity handling
- Meta-regression analysis
- Subgroup by region/time
Choose this if:
"You're studying disease prevalence, risk factors, or population health outcomes with many observational studies."
Systematic Review Only
Medium Package
$2,200 / 10-12 weeks
- 16-40 included studies
- Newcastle-Ottawa Scale
- Narrative synthesis
- Evidence tables
Choose this if:
"Your observational studies are too heterogeneous to pool, but you need rigorous qualitative synthesis."
Complete SR + Meta-Analysis
Medium Package
$2,800 / 10-12 weeks
- 16-40 included studies
- Random effects models
- Sensitivity analyses
- Publication bias tests
Choose this if:
"You have cohort or case-control studies with comparable outcomes that can be pooled statistically."
Scoping Review
PRISMA-ScR Compliant
$1,200 / 6-8 weeks
- Evidence landscape mapping
- Policy-relevant synthesis
- Gap identification
- Stakeholder input
Choose this if:
"You're mapping the public health evidence landscape or informing policy decisions on emerging issues."
Meta-Analysis Add-On
Large Package
$1,200 / +3-4 weeks
- Add to existing SR
- 26+ studies to pool
- Complex heterogeneity
- Meta-regression
Choose this if:
"You have an existing SR and want to add statistical pooling for a large, heterogeneous dataset."
Complete SR + Meta-Analysis
Enterprise Package
$5,000 / 14-18 weeks
- 81+ included studies
- Global evidence synthesis
- Multiple subgroups
- Policy recommendations
Choose this if:
"You need a comprehensive global prevalence study or WHO/CDC-level evidence synthesis."
Standalone
Meta-Analysis
$1,000 / 2-4 weeks
- You provide extracted data
- Prevalence pooling
- Freeman-Tukey transform
- Prediction intervals
Choose this if:
"You've completed data extraction and need expert statistical analysis for prevalence or risk data."
Narrative Review
Article
$1,000 / 4-6 weeks
- Expert perspective
- Thematic synthesis
- Policy implications
- Future directions
Choose this if:
"You want an authoritative overview of a public health topic with policy recommendations."
Social Sciences & Education
Educational interventions, psychological research, mixed methods, qualitative synthesis
Education Research
Psychology
Mixed Methods
Qualitative
Systematic Review Only
Medium Package
$2,200 / 10-12 weeks
- 16-40 included studies
- Thematic analysis
- Mixed methods integration
- CASP quality assessment
Choose this if:
"You're reviewing educational or psychological interventions with diverse methodologies."
Narrative Review
Article
$1,000 / 4-6 weeks
- Theory-driven overview
- Conceptual framework
- Research agenda
- Practice implications
Choose this if:
"You want a theoretical overview without strict systematic methodology requirements."
Scoping Review
PRISMA-ScR Compliant
$1,200 / 6-8 weeks
- Evidence mapping
- Emerging research areas
- Concept clarification
- JBI methodology
Choose this if:
"You're exploring a new research area or clarifying concepts before a full systematic review."
Complete SR + Meta-Analysis
Medium Package
$2,800 / 10-12 weeks
- 16-40 included studies
- Effect size calculation
- Moderator analysis
- Forest plots
Choose this if:
"You have experimental studies with comparable outcomes that can be pooled (e.g., Cohen's d)."
Systematic Review Only
Small Package
$1,500 / 8-10 weeks
- Up to 15 included studies
- Focused questions
- Narrative synthesis
- Evidence tables
Choose this if:
"You have a focused social science question with a smaller but high-quality evidence base."
Standalone
Meta-Analysis
$1,000 / 2-4 weeks
- You provide extracted data
- SMD/Cohen's d pooling
- Moderator analysis
- R code provided
Choose this if:
"You've completed your SR and need help with statistical pooling of effect sizes."
Protocol Development
Only
$500 / 1-2 weeks
- PROSPERO-ready protocol
- Search strategy
- Inclusion criteria
- Analysis plan
Choose this if:
"You want to conduct the SR yourself but need methodological guidance on protocol design."
Literature Search
Only
$400 / 1-2 weeks
- Multi-database search
- Reproducible strategy
- Deduplication
- Citation export
Choose this if:
"You have a team for screening but need expert search strategy development."
Nursing, Allied Health & Other Fields
Nursing research, physical therapy, nutrition, engineering, business, and interdisciplinary studies
Nursing
Allied Health
Interdisciplinary
JBI
Systematic Review Only
Small Package
$1,500 / 8-10 weeks
- Up to 15 included studies
- JBI critical appraisal
- Narrative synthesis
- PRISMA compliant
Choose this if:
"You're starting your first systematic review or have a focused research question in your field."
Narrative Review
Article
$1,000 / 4-6 weeks
- Expert perspective
- Practice implications
- Field-specific journals
- Quick turnaround
Choose this if:
"You want a comprehensive overview for professional journals without strict SR methodology."
Protocol Development
Only
$500 / 1-2 weeks
- PROSPERO-ready
- Methodology guidance
- Search strategy
- DIY support
Choose this if:
"You want to conduct the SR yourself but need expert help with protocol design."
Literature Search
Only
$400 / 1-2 weeks
- Field-specific databases
- Comprehensive strategy
- Grey literature
- Citation management
Choose this if:
"You have a team for screening but need information specialist expertise for search design."
Complete SR + Meta-Analysis
Small Package
$1,800 / 8-10 weeks
- Up to 15 studies
- Statistical pooling
- Forest plots
- Complete package
Choose this if:
"You have quantitative studies in your field that can be pooled statistically."
Scoping Review
PRISMA-ScR Compliant
$1,200 / 6-8 weeks
- Evidence mapping
- Gap identification
- JBI methodology
- Stakeholder input
Choose this if:
"You're exploring an emerging research area in your field before a full systematic review."
Systematic Review Only
Medium Package
$2,200 / 10-12 weeks
- 16-40 included studies
- Comprehensive search
- Quality assessment
- Narrative synthesis
Choose this if:
"You have a broader research question with moderate-sized literature to synthesize."
Revision & Resubmission
Support
$350 / as needed
- Reviewer response letter
- Manuscript revisions
- Additional analyses
- Resubmission support
Choose this if:
"You received reviewer comments and need expert help addressing them for resubmission."
Need a Custom Package?
Don't see exactly what you need? We create tailored solutions for unique research requirements. Whether you need a combination of services, specialized methodology, or have specific timeline constraints, we're here to help.
- Combine multiple services at discounted rates
- Flexible timelines to match your deadlines
- Specialized methodology for unique research designs
- Free consultation to discuss your specific needs
- Institutional & group discounts available
Request Custom Quote
Your information is secure. We respond within 24 hours.
Common Questions
Frequently Asked Questions
Everything you need to know about our systematic review and meta-analysis services.
A systematic review is a rigorous, methodologically transparent synthesis of all available evidence on a specific research question. Unlike traditional literature reviews, systematic reviews follow pre-defined protocols (registered in PROSPERO), use comprehensive multi-database searches, apply explicit inclusion/exclusion criteria, and assess study quality using validated tools (RoB 2.0, NOS, JBI).
They follow PRISMA 2020 guidelines and are considered the highest level of evidence in evidence-based medicine. When quantitative pooling is appropriate, they may include meta-analysis.
A typical systematic review takes 8-16 weeks depending on scope and complexity:
Adding meta-analysis adds 2-4 weeks depending on complexity. We also offer express delivery options for time-sensitive projects at an additional cost.
A systematic review is the comprehensive process of identifying, screening, and synthesizing all relevant studies on a topic. Meta-analysis is a statistical technique used within some systematic reviews to quantitatively pool data from multiple studies.
Meta-analysis produces forest plots, calculates pooled effect sizes (odds ratios, risk ratios, mean differences), assesses heterogeneity (I², Q-test), and tests for publication bias with funnel plots. Not all systematic reviews include meta-analysis—it depends on whether studies are sufficiently homogeneous for statistical pooling.
Yes, absolutely. Our services are fully ethical and compliant with international publication guidelines. We work as research collaborators, not ghostwriters. You remain the intellectual lead, make all critical methodological decisions, and maintain full authorship rights.
We conduct comprehensive searches across multiple databases:
We also search gray literature (OpenGrey, ProQuest Dissertations), clinical trial registries (ClinicalTrials.gov, WHO ICTRP), and conduct manual reference list screening. Our information specialists develop reproducible search strategies that you review and approve.
We use validated, study-design-appropriate quality assessment tools:
The tool selection is determined by your included study types and discussed during protocol development. All assessments are performed in duplicate with consensus resolution.
We use industry-standard statistical software:
For network meta-analysis, we use R packages (netmeta, gemtc) or Stata (network suite). You receive complete, annotated code for full reproducibility, and we provide training sessions to help you understand and explain the analyses.
Yes, PROSPERO protocol registration is included in all our systematic review packages. We prepare the complete protocol with your research question (PICO framework), search strategy, inclusion/exclusion criteria, data extraction plan, quality assessment approach, and analysis methods.
You review and approve the protocol before we submit it to PROSPERO on your behalf. Protocol registration is essential for transparency and reducing publication bias.
Our comprehensive deliverables include:
Following ICMJE authorship criteria, you maintain authorship because you:
Our role as methodological consultants and writing support is acknowledged in the manuscript per GPP 2022 guidelines. You are accountable for the work as the author.
Still Have Questions?
Our team is happy to discuss your specific project requirements and answer any questions.
Why Researchers Choose Us
Expertise You Can Trust
PhD-level methodological expertise combined with a commitment to ethical research practices and transparent collaboration.
PhD-Level Experts
Our team includes PhD statisticians, medical writers, and information specialists with extensive experience in evidence synthesis methodology.
Meet Our TeamAdvanced Statistical Analysis
From basic meta-analysis to complex network meta-analysis and Bayesian methods. Full statistical code provided for reproducibility.
View Statistical ServicesCollaborative Process
We work alongside you at every step. You approve methodology, review results, and maintain full intellectual ownership of your research.
See Our ProcessPRISMA 2020 Compliant
Every systematic review follows the latest PRISMA 2020 guidelines with registered protocols, flow diagrams, and complete checklists.
About PRISMAUnlimited Revisions
Revision support for peer review feedback is included in all packages. We help you address reviewer comments and resubmit with confidence.
Get a QuoteJournal-Ready Output
Manuscripts formatted for your target journal with cover letters, supplementary files, and all required documentation ready for submission.
View PackagesCommitted to Ethical Research Practices
All services comply with international publication ethics standards
COPE Guidelines
Committee on Publication Ethics standards for responsible research publication
Learn MoreMethodologies & Tools We Use
Industry-standard frameworks and software for rigorous evidence synthesis
📋
PRISMA 2020
Reporting Guidelines
🔬
Cochrane
RoB 2.0 & Methods
⚖️
GRADE
Evidence Certainty
📊
RevMan
Meta-Analysis
💻
R & Stata
Statistical Analysis
Free Resources
Enhance Your Research Knowledge
Expert guides and tutorials to help you understand systematic review methodology, boost your citations, and advance your academic career.
Methodology
Systematic Review vs Meta-Analysis: Key Differences Explained
Clear explanation of how systematic reviews and meta-analyses differ, when to use each, and how they complement each other in evidence synthesis.
Research Impact
Why Systematic Reviews Are the Fastest Path to a Higher H-Index
Discover why systematic reviews consistently rank among the most-cited article types and how they can accelerate your academic career and research impact.
